CD Bioparticles, a leading manufacturer and supplier of numerous drug delivery products and services, recently announced the launch of its new product 3D transfection reagents which can improve gene transfection performance and efficiency of cell lines, including Si3D Matrice Transfection Reagent and Si3D Transfection Reagent.

Three-dimensional (3D) matrices such as 3D scaffolds and 3D hydrogels can serve as mechanical platforms for cell attachment and growth. Biomaterials with viscoelastic support are capable of continuously adapting to external constraints and responding to multiple physiological stimuli, aiming to mimic the organic environment of cells. So 3D matrices allow cells to grow in vitro in a more natural way.

In contrast to two-dimensional cells, in the 3D cell model, the microenvironment in which cells grow is almost that of des in vivo microenvironment and can truly reflect the interactions between cells, between cells and matrices, and between cells and the microenvironment in vivo, which to some extent replicates the process of onset and progression of the disease. Therefore, in the last decade it has been proposed that transgenic cells grown or embedded on 3D matrices can be used as controlled drug release systems.

CD Bioparticles now offers a range of new transfection reagents to assist researchers in gene transfection and enable convenient, efficient and accurate analysis of cell cultures. CD Bioparticles team of experts ensures that the process is simple and requires no additional optimization steps.

Advantages:

• Low toxicity, safe operation
• Not of animal origin, suitable for a wide range of uses
• Compatible with various solid 3D culture scaffolds and hydrogel 3D culture media.

key applications:

• Studies on cell migration
• Metabolic and toxicological tests
• treatment of bone defects
• Assess the invasive potential of malignant tumor cells
• Investigate cell-cell interactions, such as B. killing immune cells
• Real-time monitoring of organoid differentiation and growth…