- Cyclerion Therapeutics Inc CYCN is Reprioritization of development programs and concentration of resources and skills on candidates for mitochondrial diseases.
- The Company evaluated the pharmacology of sGC stimulation with once-daily CY6463 in signal search studies in three patient populations.
- From now on, Cyclerion will focus on the future development of CY6463, initially focusing on the development of Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS).
- “We look forward to discussions with regulators later this year and the release of more detailed development plans early in the new year,” said Peter Hecht, CEO of Cyclerion.
- also read: Why the Cycllerion therapeutics share is hammered
- The company is preparing for a meeting with the FDA to discuss the CY6463 development program.
- Cyclerion is also developing CY6463 in patients with cognitive impairment associated with schizophrenia (CIAS) and Alzheimer’s disease with vascular pathology (ADv).
- According to Cyclerion, CY3018 is well suited for the treatment of Cias and other neuropsychiatric indications. Cyclerion is conducting pre-IND activities for CY3018 and is looking for a partnership or other funding mechanism to further develop the program in the future.
- The company has limited the admission to its current clinical ADV study. Data from the ADV study are expected in the first half of 2023.
- The company reduced its workforce by approximately 45% to 16 full-time employees and will incur a one-time fee of $1.9 million and achieve annual savings of approximately $4.1 million.
- Price promotion: The CyCN shares fell to $ 42.58 % to $ 0.5399 on the last check-on.
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