GH/IGF-1 physiologically decreases with age, and these changes are accompanied by fatigue, muscle atrophy, increased adipose tissue, and cognitive decline in the elderly…

In 1990, Rudman published an article in the New England Journal of Medicine that shocked the medical community, “The Use of Human Growth Hormone in People Over 60 Years of Age.” Rudman selected 12 men, ages 61 to 81, for clinical trials:

After 6 months from hGH injection, subjects had an average increase in muscle mass of 8.8%, fat loss of 14.4%, skin thickening of 7.11%, bone density of 1.6%, liver of 19% compared to the other elderly controls % and the spleen by 17% at the same age. % it was concluded that the histological changes were 10 to 20 years younger in all subjects.

This conclusion has led to widespread promotion of recombinants human growth hormone (rhGH) as an anti-aging drug, and it is also the main reason why many people believe that injecting rhGH can counteract aging. Since then, many clinicians have used hGH as an antiaging drug, even though it’s not FDA approved.

However, as the research continues to deepen, scientists have found that the small benefits to the body of increasing GH/IGF-1 axis activity don’t actually extend lifespan in older people, but instead pose health risks:

Mice that oversecrete GH are huge but have a 30-40% shorter lifespan than wild-type mice [2]and histopathological changes (glomerulosclerosis and hepatocyte proliferation) occur in mice with elevated GH levels. large) and insulin resistance.

High levels of GH stimulate the growth of muscles, bones, and internal organs, leading to gigantism (in children) and acromegaly (in adults). Adults with excess GH are often associated with diabetes and heart problems, as well as a higher risk of cancer.

Source: https://www.gentolexgroup.com/news/does-growth-hormone-slow-or-accelerate-aging/

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