GENEVA, SWITZERLAND / ACCESSWIRE / August 24, 2022 / RELIEF THERAPEUTICS Holding SA (SIX:RLF)(OTCQB:RLFTF)(OTCQB:RLFTY) (“Relief”) announced today that it has filed a registration statement on Form F-1 under the Securities Act of 1933 with the United States Securities and Exchange Commission (“SEC”) relating to a proposed offering of its common shares in the form of American Depositary Shares ( “ADSs”). The number of ADSs to be offered, the plan for distributing the ADSs, and the price range for the proposed offering have not yet been determined. Relief plans to apply to list its ADSs on the NASDAQ exchange under the symbol “RLFT”, although there can be no guarantee that this will be successful. There can be no assurance as to whether or when the Offering may be completed, or as to the actual scope or terms of the Offering. The offer, if made, will only be made by means of a valid prospectus.

Relief’s ADS program complements the existing primary listing of its common stock on the SIX Swiss Exchange. Relief’s common shares are listed on the SIX Swiss Exchange under the symbol “RLF” and will be listed in the United States on the OTCQB market under the symbol “RLFTF”. Relief’s ADSs, each representing one hundred fifty (150) shares of Relief’s common stock, are currently listed on the US over-the-counter market under the trading symbol “RLFTY”.

A registration statement on Form F-1 relating to the proposed sale of Relief’s ADSs has been filed with the SEC but has not yet become effective. Such securities may not be sold nor may offers to buy such securities be accepted prior to the time the Registration Statement becomes effective.

This press release does not constitute an offer to sell or a solicitation of an offer to buy any securities in the United States or any other jurisdiction, nor does it constitute an offer or sale of any securities in the United States or any other jurisdiction.